منابع مشابه
High LET constraints on low LET survival.
Survival curves for biological cells irradiated with gamma rays (and other low LET radiations) cannot be properly interpreted without examining the implications of these interpretations for high LET radiations. The theory of RBE demands that the RBE of any high LET radiation field is at most one when the probability for cell killing as a function of the absorbed dose of gamma rays is linear or ...
متن کاملLow dose hypersensitivity after high-LET irradiation
An unexpected hypersensitivity has been reported for several cell lines at low doses (<1Gy), which is not consistent with the linear-quadratic approach currently used in general for the description of survival curves [1,2,3,4]. The corresponding substructure of the survival curves has been attributed to induced radioresistance. There are indications, that high-LET irradiation with neutron or pi...
متن کاملScaling Human Cancer Risks from Low LET to High LET when Dose-Effect Relationships are Complex.
Health risks from space radiations, particularly from densely ionizing radiations, represent an important challenge for long-ranged manned space missions. Reliable methods are needed for scaling low-LET to high-LET radiation risks for humans, based on animal or in vitro studies comparing these radiations. The current standard metric, relative biological effectiveness (RBE) compares iso-effect d...
متن کاملRBE-LET relationships of high-LET radiations in Drosophila mutations.
The relative biological effectiveness (RBE) of 252Cf neutrons and synchrotron-generated high-energy charged particles for mutation induction was evaluated as a function of linear energy transfer (LET), using the loss of heterozygosity for wing-hair mutations and the reversion of the mutant white-ivory eye-color in Drosophila melanogaster. Loss of heterozygosity for wing-hair mutations results p...
متن کاملComparison of the bromodeoxyuridine-mediated sensitization effects between low-LET and high-LET ionizing radiation on DNA double-strand breaks.
The incorporation of halogenated pyrmidines such as bromo- and iodo-deoxyuridines (BrdU, IdU) into DNA as thymidine analogs enhances cellular radiosensitivity when high-linear energy transfer (LET) radiation is not used. Although it is known that high-LET ionizing radiation confers fewer biological effects resulting from halogenated pyrimidine incorporation, the exact mechanisms of reduced radi...
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ژورنال
عنوان ژورنال: Physics in Medicine and Biology
سال: 1978
ISSN: 0031-9155
DOI: 10.1088/0031-9155/23/5/007